However, stranger things have happened in football and Arsene Wenger should aim to leave Switzerland with all three points, as they prepare to face bottom placed FC Basel on Tuesday evening.
The Swiss side, who are runaway leaders in their domestic campaign, will know that a win will likely guarantee them Europa League qualification. Here are four men that Arsenal need to be wary of at the St. Jakob-Park Stadium...
4. Birkir Bjarnason
The 28-year-old midfielder may be an all too familiar face to some English fans, as a result of his Euro 2016 antics.
Bjarnason was part of the heroic Icelandic squad that reached the quarter finals and he scored his nation's first ever goal in a major tournament, in their opening game against eventual winners Portugal.
Bjarnason has continued his summer form into the new season and has been a major part of Basel's success in the domestic league. The former Sampdoria man has 10 goals in all competitions in what is his second season in Switzerland.
3. Taulant Xhaka
It could be a Xhaka showdown in the middle of the park, if Arsene Wenger opts to select Granit to play against his brother Taulant. The latter is the elder of the two, at 25 years of age, and unlike Granit, plays for the Albanian national side.
An uncompromising defender, Xhaka's passion ignites the entire FC Basel side and if he gets a chance to get a hold of the ball, the Gunners could be in serious trouble of losing themselves.
2. Matias Delgado
The man who makes things tick for Basel, Delgado is on course to record his best ever numbers in terms of goals scored, with the Argentinian playmaker already registering 11 goals this season.
The 33-year-old veteran is in his second spell at the club, having left to spend spells in Turkey with Besiktas and in the UAE with Al-Jazira, but he is back to his best and will be the main provider for Basel chances.
1. Marc Janko
The experienced journeyman Janko has scored goals wherever he has gone; from the Netherlands and Portugal to Turkey and Australia. Now in his second season in Switzerland with FC Basel, the 33-year-old has 16 goals already this campaign.
The Austrian international uses his height effectively and could prove extremely problematic for the Arsenal central defenders. Janko has yet to score in the Champions League this season and will be keen to end the campaign with at least one goal.